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Subcutaneous injection near the injury site delivers high local concentrations while still providing systemic distribution through circulation
In the Phase 2 trial, participants who started directly at 4 mg (without the 2 mg titration period) experienced nearly double the rate of gastrointestinal adverse events compared to those who started at 2 mg (Jastreboff et al., NEJM 2023)
Injections administered in NHS primary care settings do not typically incur prescription charges in England, though arrangements may vary
Concurrent application with highly acidic or strongly chelating topical agents-such as concentrated ascorbic-acid serums-may reduce the activity of one or both products because copper ions can catalyze oxidation reactions
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